Can I mix up the entire package with water, or do I have to mix before each use?

If you want to pre-mix, you can mix enough for a week, and store in the refrigerator. This is to prevent any potential bacterial development from a high water environment. We recommend mixing a single portion, just before brushing. By the time you’ve spent your 2 minutes brushing all of the crystals are dissolved and you’re ready to swish and gargle.

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